How much detour are you willing to make?
Will your wife be playing? Walking with you? Waiting for you?
If the weather's good, consider a detour in the NC mountains to Sugaree or Ashe County. Two great experiences, it will be peak fall color at that time.
Another alternative are two courses near Savannah, Tom Triplett & The Sarge, which are both pretty good and both virtually on the interstate exit ramps. (Assuming your I-77 route is to Columbia, then I-26 and I-95 to Florida.
Otherwise, Charlotte on the I-77 route. Choosing only 1 course of the dozen or so there, what kind of course do you want? Whether easy or tough, tight or open, the Charlottans will have something to offer.