If you are going 5 up. You might be able to swing by Shady Oaks and Rocklin in the Sac area. Shady is about 30 min off of 5 and then you can back door Rocklin (Hazel/Sierra College). Then you could take 65 to 20. 20 will take you through Clear Lake to Ukiah onto 101. Mind you this is all off the top of my head. I was also assuming you'de be taking 20 over to 101 anyway?
1 all the way back will be tough. Mainly on the north side of the Golden Gate Bridge. It chews up A LOT of time from Fort Bragg to Bodega Bay, but if you're looking for the scenic route? It's pretty. Tomales and Point Arena are some nice places to stop and eat (bakery in Tomales only). Going that route. The only course you might miss is Stafford, but there are some country roads that can get you close if it's a must on your list.
Once you get south of the GGB. 1 is easy to pick up after you play GGP. Another cool town to rest a bit is Half Moon Bay. Then you're only about an hour + from Santa Cruz. If you dig New York style Pizza. Pizza My Heart in Santa Cruz is a must!
Have a great time!
If you would like a tour guide for GGP drop me a PM. If I'm around, I'd be happy to show you around.