rolling your wrist, pulling your disc durring follow through, or just throwing too hard!
slow it down, find a speed that you can throw it straight, then slowly start throwing it harder as you get that release point down.. eventually you will be able to throw it hard and straight at the same time.
If your throwing it too hard, your not going to get a straight release.
This. The Axis is nose angle sensitive and will punish bad form. Keep practicing and you will see positive results!