If you can throw 400 dead straight, well then you probably don't need any pointers from me. Barring that, the most obvious and best way to play this hole is to dial down the center with a perfectly straight mid-range disc. Two clean shots at 215+ feet will get you a putt for birdie on this par 4.
If you can't throw straight to save your life, rest assured that you still have a shot at 3. Drive at least half way down the hole, then if you fade left just past the tree line, you'll have a clean shot down the side. There's some hanging branches that make an anhyzer a little scary, but a forehand shot with a nice skip will put you right under the basket for a back door 3.
I am going to say that I agree with bigbeano's tip about this hole. I always throw my Buzz and I don't try and rip all 400+ feet on the first toss. It is better to be 250 in the fairway then 300 and way off to the side or out of bounds after a bad deflection off a tree.
Whatever you do, keep your drive very low. The more height you get behind it, the more chance it will fade directly in the treeline. It may be better to tee-off with a super straight mid range to hopefully avoid late fade and keep you in the middle.