I think this has some merit but can be done incorrectly quickly.
The original pin at hole 4 at Zebulon is a classic example of a par 4 that people argued was neutral b/c the tee shot was a RHBH hyzer and the upshot was a LHBH hyzer but it was very lefty friendly.
Here is the course.
http://www.dgcoursereview.com/course.php?id=2045&mode=hi#
The pin used to be tucked over to the right behind the softball field.
Even with a perfect drive, a right handed player would have to throw a roller, sidearm, thumber or a very flippy disc. Be close to the fence and there was no good option. Be far left you had a very low ceiling left to right shot.
Now the tee shot was a pretty easy RHBH hyzer, but the key to scoring on par 4's is the 2nd shot. The ideal landing zone on a tee shot could easily be missed by 75 feet in any directon - including backwards - and a left handed player would have a good chance of making three.
If you miss your upshot by 75 feet, not only are you outside the circle on 3 of 4 directions, the 4th direction is out of bounds.