At 425'+ power the Defender in Bio will turn into hard wind for you. Maybe not initially, but after the beat in period of even a month with that plastic it will be like -2/2 into wind I bet. Basically it cannot be your overstable bookend disc, but it could be a good stable-overstable distance driver in calm and usable in lots of wind, but you need something truly OS as well.
I think I have thrown one Gladiator in Opto, no experience with the Cutlass, and have thrown a handful of Enforcers but never owned one. Basically the Gladiator in Opto seemed similar to a Defender in Lucid, where it was quite OS and had an earlier sweeping/gliding fade. I just really like the Defender feel and when discs are that OS I can't really tell the difference. I'd need to either bag both for a while to beat them in, or throw them in 10-20MPH wind to really see their differences.
In comparison the Bio Defender is much straighter than Lucid before going into the lengthy sweeping but aggressive fade, and it beats in soon to show turn. In Lucid the disc feels true OS for me with good HSS, but I haven't thrown it in the conditions to really push it to its limits. Whereas the Bio has the tendency to be negative HSS and you know this if you have the the power you do.
What I like about the bio Defenders I have thrown, is even when fresh and beefy they fly the same line as my beefy star Destroyer but give me 10-15' more distance on the exact same line and power. What I don't like is that they beat in to turn a bit, whereas that Destroyer has been in my bag for maybe 3 years and it's still my OS driver slot that I will throw full power BH or FH into any wind. Basically in <10MPH wind I'd rather throw a Defender, but when I absolutely need to trust the stability I use the Destroyer. I do not bag both at the moment because at my power it would be redundant.
Enforcer feels smaller rim width, Defender is like a Destroyer but slightly wider, whereas Enforcer is more Wraith width. I feel that the fade on the Enforcer knifes in a bit more rather than gliding/pushing...like say a beefy Thunderbird compared to a Firebird. I can throw the Defender farther at my power which is 400ish golf lines with straighter drivers, so you have a bit more power. Bio Enforcers do seem to hold straight for quite a long time before the hard fade comes in. I don't have the power to push Lucid Enforcer to the limits to see what they do. All I can say for their stability is that DD pro's tend to bag some Defenders for trusty distance, but they all need some Enforcers or at minimum Lucid Defenders that they pick out for true OS in wind. Beat Bio Enforcers seem to get very straight at high power like a beat in XCal, whereas beat in Bio Defenders get a wider flight path for max distance like a beat in Destroyer.