I'd notice if blindfolded, but that's not what is important. It's the throw that's important.
I could throw either beaded or beadless, but for me the beadless Warden beat out the beaded Judge. And it felt a little bit better, too. Since then, I've practiced and played with the Warden almost all the time. Recently I took a Classic Judge to the course, and found that the bead was impeding my throw and causing me to push the disc to the right (and miss). I put the Warden back in the bag, and putting returned to normal (didn't miss as much).
It was not the bead itself that was the issue, nor the feel of the discs in my hand, but the fact that by now I'm so used to beadless discs, and the Warden in particular, that going to a beaded disc would require a LOT of practice to get the beaded disc working well for me.
So is it physically how "big" the bead is at the bottom where the touch point is probably mm more than non beaded? Or is it psychological?
And what grip are you using?